Kaneka Corporation

Souichi Morikawa

Kozo Yamamoto

Yoshihide Fuse

Mikio Kitahara

Shin-ichi Yokota

Sakayu Shimizu

Yoshihiko Yasohara

Noriyuki Kizaki

Michihiko Kataoka

Teruaki Takesue

Takahisa Nakai

Miho Yano

Takayoshi Hidaka

Eiji Ogino

Tatsumasa Mae

Ai Yonezawa

Yoshitomo Sakamoto

Masashiro Funaki

Masahiro Funaki

The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.

Carbonyl reductase, gene thereof and method of using the same

The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber. The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.

Peptide capable of binding to insulin-binding protein and adsorbent

A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

Methods of treating cancer using a heat shock factor activity inhibitor

Heat shock factor activity inhibitor

Heat shock factor activity inhibitors

The present invention has for its object to provide a medicinal composition comprising coenzyme Q,as an active ingredient, which composition features an enhanced absorption after oral administration. The present invention is directed to a medicinal composition comprising coenzyme Q,as an active ingredient with the reduced form of coenzyme Q,accounting for more than 20 weight % of said coenzyme Q,.

Pharmaceutical composition comprising coenzyme Q10

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Hyogo, Japan

Souichi Morikawa