William Marsh Rice University

Sotirios Totokotsopoulos

Kyriacos Costa Nicolaou

Derek Rhoades

Yanping Wang

In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided. 

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Chicago, IL, United States of America

Sotirios Totokotsopoulos