Novozymes A/s

Other

Soren Kjaerulff

Carsten Schau Andersen

Allan Svendsen

Christel Thea Jorgensen

Henrik Bisgaard-Frantzen

Henrik Bisgard-Frantzen

Claus Crone Fuglsang

Thomas Thisted

Jack Bech Nielsen

Michael Anders Godskesen

Peter Nordkild

Steven Paul Georges Cooremans

Georg Rudolf Theobald Bechmann

The present invention relates to methods for treatment or prevention of liver, biliary tract, and pancreatic disorders by administering one or more defensins. Included within the scope of the disclosure is also treatment of certain metabolic disorders.

Treatment of liver, biliary tract and pancreatic disorders

The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.

Alpha-amylase variants

The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased.

A method for testing cleaning effect of a compound or compositions is disclosed. The method comprises:

Automated mechanical stress assay for screening cleaning ingredients

The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered stability, in particular at high temperatures and/or at low pH relative, and/or low Cato the parent alpha-amylase.

Alpha-amylase mutants with altered properties

A transgenic plant cell expressing a maltogenic amylase (such as Novamyl&#xae;) or a beta-amylase; a transgenic plant regenerated from said cell; seeds generated from such plant where said seeds comprise a maltogenic amylase or a beta-amylase and the use of said seeds, optionally in ground form, for catalyzing an industrial process, such as e.g. in baking. The maltogenic amylase providing an anti staling effect in bread produced from the seeds in question.

Transgenic plant expressing maltogenic alpha-amylase

The invention relates to a variant of a parent Termamyl-like &#x3b1;-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an &#x3b1;-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an &#x3b1;-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an &#x3b1;-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an &#x3b1;-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like &#x3b1;-amylase, which variant exhibits increased.

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Vanlose, Denmark

Soren Kjaerulff