Medtronic Minimed, Inc.

Novo Nordisk A/s

Precisense A/s

Nna/s

Soren Aasmul

Jesper Svenning Kristensen

Rajiv Shah

Katherine T Wolfe

Anubhuti Bansal

Tri T Dang

Jens Ulrik Poulsen

Lars Hofmann Christensen

Robert McKinlay

Joseph Hanna

Eric Allan Larson

Henrik Egesborg

Henrik Ljunggreen

Jasson Rodriguez

Henning Munk Ejlersen

Jens Moller-Jensen

Kevin F Holz

Ameya S Kantak

Voltaire Isaac Lebron

Jakob Janting

Daniel Aaskov

Joseph F Hall

Peter Moller-Jensen

Ameya Kantak

Kevin Holz

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

Orthogonally redundant sensor systems and methods

The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.

Modified-dextrans for use in optical glucose assays

Using a blue-shifted reference dye in an optical glucose assay

A device for detection or measurement of a carbohydrate analyte in fluid comprises: The device may be combined with an insulin-infusion system.

Sensor with optical interface

A new biostable glucose permeable polymer has been developed which is useful, for example, in implantable glucose sensors. This biostable glucose permeable polymer has a number of advantageous characteristics and, for example, does not undergo hydrolytic cleavage and degradation, thereby providing a composition that facilitates long term sensor stability in vivo. The versatile characteristics of this polymer allow it to be used in a variety of contexts, for example to form the body of an implantable glucose sensor. The invention includes the polymer composition, sensor systems formed from this polymer composition, and methods for making and using such sensor systems.

Biostable glucose permeable polymer

Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.

Methods for making an aqueous radiation protecting formulation

Aqueous radiation protecting formulations and methods for making and using them

A first light source emits a light signal along a measurement optical path that includes a sample and a second light source emits a light signal along a dummy measurement optical path. A measurement circuit receives the light signals and provides outputs separated in time which are indicative of the phase of the respective light signals. A phase shift is induced in light in the measurement optical path by the sample. A reference circuit receives a signal indicative of the phase of the light signals emitted by the first and second light sources. Circuitry compares the phases of light output from the two circuits to provide output indicative of a first measured phase difference during operation of the first light source. Correction is applied to this measurement by taking a similar phase difference measurement during operation of the second light source and comparing the two phase differences.

Method and apparatus for measuring the phase shift iduced in a light signal by a sample

Method and apparatus for measuring the phase shift induced in a light signal by a sample

A method of self treating a disease, such as diabetes, includes collecting in one or more databases data representing values of parameters that related to the self treatment. The data is processed to provide a plurality of alternate choices between two or more actions that may be taken and a corresponding value for each action is calculated. A computerized system may be employed to perform the above method and the system may include a computer readable medium for executing the method.

Method and a system for assisting a user in a medical self treatment, said self treatment comprising a plurality of actions

A drug delivery device comprising a housing ( ) with a drug container ( ) being provided with delivering means comprising a piston ( ) for expelling a drug ( ) from the drug container ( ). The housing ( ) further comprising a displaceable piston rod ( ) abutting the piston ( ) of the drug container ( ) and rotating means being in engagement with the piston rod ( ), said rotating means being provided with a one-way mechanism. The one-way mechanism comprises a helical spring ( ) wound tightly around an axle ( ), one end of said helical spring ( ) being fixed in relation to the housing ( ), the other end of the helical spring ( ) being in a free state.

Drug delivery device provided with a one-way mechanism

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Holte, Denmark

Soren Aasmul