Nestec S.a.

Danisco A/s

Societe Des Produits Nestle S.a.

Sophie Helene Nutten

Annick Mercenier

Guenolee Prioult

Monique Julita

Clara Lucia Garcia-Rodenas

Valerie Petit

Gregory Leyer

Véronique Dennin

Bruno Pot

Carine Blanchard

Alexandre Panchaud

Valerie Francoise Verhasselt

Swantje Duncker

Velerie Petit

Clara Garcia-Rodenas

Nanda De Groot

The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of non-replicatingLa1 NCC533 (deposit number CNCM I-1225) for use in the treatment or prevention of disorders related to the immune system including infections.

La1 NCC533 (CNCM I-1225) and immune disorders

This invention relates to the administration of a combination of TGF-&#x3b2; and one or more peptides comprising specific sequences of &#x3b2;-lacto-globulin. The peptides are hypoallergenic but retain the capability to induce tolerance to the native protein. The combination of TGF-&#x3b2; and one or more of these peptides has the therapeutic effect of inducing and maintaining oral tolerance towards newly introduced proteins, in particular, at the weaning period. The combination can modulate the infant and toddler immune response to allergens.

Combination of tolerogenic peptides and TFG-B for use in the induction and maintenance of oral tolerance in young mammals

The invention relates to newly identified peptides of that are capable of inducing tolerance to cow's milk, especially to &#x3b2;-lactoglobulin. The peptides may be administered to mammals, especially to young infants who are at risk of allergy to cow's milk proteins, to induce oral tolerance to cow's milk; they may also be administered to children or adults who are allergic to cow's milk to allow 'desensitization' towards the allergenic milk proteins, especially &#x3b2;-lactoglobulin, to occur. The peptides may also be used to induce tolerance to goat's and buffalo's milk proteins, especially &#x3b2;-lactoglobulin. The peptides are capable of modulating the mammalian immune response to allergens.

Newly identified peptides for use in the induction of oral tolerance in young mammals

CNCM I-3865 (NCC2950), a composition comprisingCNCM I-3865 (NCC2950), and the use ofCNCM I-3865 (NCC2950) in the prevention or treatment of allergic diarrhoea are provided. TheCNCM I-3865 (NCC2950) can be in a non-replicating form and can be administered to at least partially treat allergic diarrhoea or at least partially reduce the risk of developing allergic diarrhoea.

Prevention and treatment of allergic diarrhea

The present invention relates to the field of infant nutrition. In particular, the present invention relates to infant feeding formulas comprising probiotic micro-organisms. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example.

Infant feeding formulas comprising probiotic micro-organisms

The present invention relates to non-replicating probiotic micro-organisms and their health benefits. For example, the present invention relates to compositions comprising non-replicating probiotic micro-organisms for use in the treatment of prevention of upper respiratory tract infections and/or their symptoms. Embodiments of the present invention provide means to help parents to protect their children from such upper respiratory tract infections.

Non-replicating probiotic micro-organisms protect against upper respiratory tract infections

The present invention relates to non-replicating probiotic micro-organisms and their health benefits. In particular, the present invention provides a means to help parents to protect their children from gastro-intestinal infections, in particular diarrhea. One embodiment of the present invention relates to a composition comprising non-replicating probiotic micro-organisms for use in the prevention or treatment of gastrointestinal infections in children.

Non-replicating probiotic micro-organisms protect children against gastrointestinal infections

The present invention relates to the field of infant cereals. In particular, the present invention relates to the field of infant cereals that can be used to strengthen the immune system of the infant and/or that can be used to treat or prevent inflammatory disorders. For example these benefits can be provided by probiotic micro-organisms. An embodiment of the present invention relates to an infant cereal comprising non-replicating probiotic-micro-organisms, for example bioactive heat treated probiotic micro-organisms.

Infant cereal comprising non-replicating probiotic microorganisms

The present invention relates to the field of frozen yoghurt. In particular, the present invention provides frozen yoghurt compositions comprising non-replicating probiotic micro-organisms. These non-replicating probiotic micro-organisms may bioactive heat treated probiotic micro-organisms, for example. The present inventions also relates to health benefits provided by these non-replicating probiotic micro-organisms.

Frozen confections containing probiotic micro-organisms

The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use ofNCC2705 (deposit number CNCM 1-2618) for use in the treatment or prevention of disorders related to the immune system including infections.

Bifidobacterium longum NCC2705 (CNCM I-2618) and immune disorders

The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defenses. One embodiment of the present invention is the use ofNCC2705 (deposit number CNCM 1-2618) for use in the treatment or prevention of disorders related to the immune system including infections.

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The present invention relates to the fields of hydration and nutrition for dysphagic patients. In particular, the present invention relates to thickeners comprising probiotic microorganisms and to compositions comprising such thickeners. The probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic microorganisms.

Instant thickener comprising probiotics for hot or cold foods and beverages to be administered to dysphagic patients

The present invention relates to the field of nutrition for children. In particular, the present invention relates to the nutritional compositions intended for children with an impaired function of the gastro-intestinal tract. One embodiment of the present invention relates to a nutritional composition to be administered to children with an impaired function of the gastrointestinal tract comprising probiotic micro-organisms. The probiotic micro-organisms may be non-replicating, for example bioactive heat treated probiotic micro-organisms.

Complete liquid nutrition for children at the age of 1-10 years comprising probiotics

The subject of the present invention is a bacterial composition having immunomodulation properties comprising at least one strain selected from the group consisting ofPTA-4797,PTA-4799,PTA-4800,PTA-4798,PTA-4801 andPTA-4802. An other subject of the invention is an immunomodulation method comprising the step of using the at least one strain selected from the preceding group.

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Palezieux-Village, Switzerland

Sophie Helene Nutten