Centre National De La Recherche Scientifique

Université Paul Sabatier (Toulouse III)

Institut National Polytechnique De Toulouse

Teknimed

Sophie Cazalbou

Christian Rey

Christèle Combes

Hélène Autefage

The present invention concerns composite biomaterials comprising ceramic and a biodegradable polymer gel, with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.

Composite biomaterials with improved bioactivity and their use for bone substitute

The present invention concerns ceramics having a modified surface with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.

Modified ceramics with improved bioactivity and their use for bone substitute

The present invention relates to a porous biomaterials surface activation method by coating with a layer of apatitic nanocrystals in order to increase their surface reactivity. The method according to the invention is characterized by the following steps: a) preparing a nanocrystalline apatitic calcium phosphate analogous to bone mineral by mixing a calcium salt solution with a phosphate salt solution in a Ca/P ratio ranging between 1.3 and 2 at a temperature ranging between 0 and 60 &#xb0; C., b) slurrying the mixture obtained in step a) in an aqueous solution so as to obtain a fluid, homogeneous paste containing 80 to 98% of water, c) bringing a porous biomaterial into contact with the suspension obtained in step b), d) drying the porous biomaterial at a temperature below 100 &#xb0; C.

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Rebigue, France

Sophie Cazalbou