Genentech, Inc.

Sophia S Kuo

Napoleone Ferrara

Austin L Gurney

William I Wood

Audrey Goddard

Paul J Godowski

Victoria Smith

Colin K Watanabe

Luc Roland Desnoyers

Kevin P Baker

Ellen Filvaroff

Dan L Eaton

Daniel Tumas

Kenneth J Hillan

Timothy Andrew Stewart

Margaret Ann Roy

James Pan

Mary E Gerritsen

Wei-Qiang Gao

J Christopher Grimaldi

Avi J Ashkenazi

Sherman Fong

David Botstein

Nicholas F Paoni

David L Shelton

P Mickey Williams

Robert D Klein

Mary A Napier

Hanspeter Gerber

Ivar J Kljavin

The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

Polypeptides homologous to VEGF and BMP1

Antibodies to polypeptides homologous to VEGF and BMP1

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

PRO363 polypeptides

PRO792 nucleic acids

Secreted and transmembrane polypeptides and nucleic acids encoding the same

Uses of VEGF-E

Nucleic acids encoding vascular endothelial cell growth factor-E (VEGF-E)

The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E is shown herein to induce enhanced survival of cells, proliferation of cells and hypertrophy of cells. Thus, VEGF-E can be useful in wound repair, as well as the generation and regeneration of tissue.

Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1

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Burlingame, CA, United States of America

Sophia S Kuo