Immusol, Incorporated

Soonpin Yei

Jack R Barber

Richard Tritz

Peter J Welch

Mang Yu

The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.

Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries

This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (&ldquo;HCV&rdquo;) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.

Hepatitis C Virus ribozymes

This invention provides ribozymes useful to treat or prevent Hepatitis C Virus ('HCV') infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes useful in methods of treatment and prevention of HCV infection or disease are also provided.

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Carlsbad, CA, United States of America

Soonpin Yei