Ono Pharmaceutical Co., Ltd.

Soonih Kim

Seiei Sasatani

Kazuhisa Takeda

Yoshiharu Kimura

Akio Nishiura

A polyurethane (I) of 1000 to 100,000 in average molecular weight, comprising plural segments, which are each structural units of A-B, A-C and A-D of the formulae: ##STR1## the proportion of the said segments of A-B, A-C and A-D, i.e. x:y:z is in the molar ratio 0.01 to 0.8:0 to 0.80:0 to 0.99, provided that the sum of x, y and z is 1.0; each segment being produced by combining with repeat units of A, B, C and D of the formulae: ##STR2## wherein R.sup.1 is a skeleton of a diisocyanate and the three R.sup.1 's in each of segments A-B, A-C and A-D can be the same or different; aza is a group of the formula: ##STR3## wherein Y.sup.1 and Y.sup.2 which can be the same or different, are oxygen, imino(--NH--) or a group of the formula:

Azo containing polyurethanes for drug delivery to the large intestines

The present invention relates to new pharmaceutical compositions characterizing that esters or amides are suspended or dissolved in a middle chain glyceride or a mixture thereof. These pharmaceutical compositions inhibit the degradation of the active ingredient (i.e. ester or amides) by the action of various digestive enzymes in digestive system.

Pharmaceutical compositions comprising esters or amides as active

The present invention relates to new pharmaceutical compositions characterizing that esters or amides are suspended or dissolved in a middle chain glyceride or a mixture thereof. These pharmaceutical compositions inhibit the degradation of the active ingredient (i.e. esters or amides) by the action of various digestive enzymes in digestive system.

The present invention relates to new pharmaceutical compositions characterizing that esters or amides are suspended or dissolved in a middle chain glyceride or a mixure thereof. These pharmaceutical compositions inhibit the degradation of the active ingredient (i.e. esters or amides) by the action of various digestive enzymes in digestive system.

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Osaka, Japan

Soonih Kim