Enzytech, Ltd.

Soon Ook Hwang

Dae Myoung Yun

Chang-min Kim

Sun Ho Chung

Racemic or optically active D- or L-&#x3b1;-glycerophosphoryl choline solids are prepared from liquid type racemic or optically active D- or L-&#x3b1;-glycerophosphoryl choline using an organic solvent. The solids are produced at a high yield more easily through phase transformation than an existing method using a difference in solubility in a solvent.

Method for preparing racemic or optically actived D- or L-A-glycerophosphorylcholine solids

The present invention is characterized in that racemic or optically active D- or L-&#x3b1;-glycerophosphoryl choline solids are prepared from liquid type racemic or optically active D- or L-&#x3b1;-glycerophosphoryl choline using an organic solvent. The present invention can produce solids at a high yield more easily through phase transformation rather than a method using a difference in solubility in a solvent, which is an existing method.

Method for preparing racemic or optically active D- or L-A-glycerophosphoryl choline solids

A method of preparing racemic or optically active D or L-&#x3b1;-glycerophosphorylcholine in large amounts by subjecting choline phosphate or a salt thereof, and racemic or optically highly pure (S) or (R)-3-halo-1,2-propanediol to a substitution reaction in a medium at high temperature in the presence of an inorganic base which increases the activity of the reaction. The method is cost-effective because of the use of starting materials which are inexpensive compared to those in a conventional method. Moreover, the method is simple and convenient because it is performed via a one-pot reaction without a separate purification process. In addition, it enables a large amount of racemic or optically active D or L-&#x3b1;-glycerophosphorylcholine, or a salt thereof, to be quantitatively produced in a medium without side reactions by using the inorganic base which increases the reaction activity.

Method for preparing racemic or optically active &#x3b1;-glycerophosphorylcholine

The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic &#x3b2;-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active &#x3b2;-hydroxybutyl ester derivatives and their acid derivatives by stereospecific hydrolysis of racemic &#x3b2;-hydroxybutyl ester derivatives using Upases or lipase-producing microorganisms in the aqueous phase or organic phase including aqueous solvent. The method of making optically active ester derivatives and their acid derivatives by hydrolysis of &#x3b2;-hydroxybutyl ester derivatives represented by the general formula 1 in scheme 1 is easier and more economical comparing to the conventional methods and the products have high optical purity. Also separation of ester derivatives from acid derivatives is easy after reaction. Thus this method is a useful process on the industrial scale.

Growing community of inventors

Daejeon, South Korea

Soon Ook Hwang