Korea Institute of Science and Technology

Soon-Hyouk Lee

ChangJoon Justin Lee

Eun Mi Hwang

Jung-Eun Park

Kye-Jung Shin

Soo Jin Oh

Eun-Joo Roh

Dong-Gyu Kim

Dong Ho Woo

Yun-Soo Na

Jeong Eun Yang

Hee-jung Chun

Wan-Keun Ji

The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof,  wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Phenoxypropanol derivative and pharmaceutical composition including the same

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Daejeon, South Korea

Soon-Hyouk Lee