Dong-A St Co., Ltd.

Dong-A Pharm. Co., Ltd.

Soon-Hoe Kim

Mi-Won Son

Weon-Bin Im

Sun-Yeou Kim

Sung-Hak Choi

Hye-Ju Kim

Ja-Young Ryu

Sang-Zin Choi

Mi-Yeon Kim

Ji Hye Lee

Sun-Ho Choi

Hyun-Jung Sung

Jung-Sang Park

Byung Jun Jang

Kang-Hun Cho

Hyun Jung Kim

Seung Hyun Song

Eunjin Kim

Min-Jung Lee

Eun Jung Kim

Sung Pil Choi

Kyung Kyun Kang

Dong-Sung Kim

Yong-duck Kim

Heung Jae Kim

Moo-Hi Yoo

Sun-Woo Jang

Seul Min Choi

Kyung Koo Kang

Chong-Hwan Cho

Seung-Bum Ha

Hyung Ki Lee

Ji Hyun Sung

Byoung Hwa Son

Chae Lim Ryu

Hae Hum Jung

Jang Hyun Park

Ju Mi Kim

Chul-Jun Bae

Han Kook Chung

Jae-Sung Hwang

Myung-Joo Kang

Kyung-Wan Ma

Ju-Hee Sohn

Tae-Kyoung Sohn

Won-Bae Kim

Min-Sun Chang

Eun-Ha Kim

Yong-Duck Kim

Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb extract of a mixture of 3.5:1Rhizoma:(w/w). Having the ability to synergistically increase in vivo levels of nerve growth factor, compared to the extracts from the herbs alone or herb mixtures of other weight ratios, the mixed herb extract is effective for preventing the apoptosis of nerve cells and promoting nerve regeneration. Thus, it can be applied to pharmaceutical compositions and health functional foods preventive and curative of diabetic peripheral neuropathy.

Composition comprising the extract of herbal combination for preventing or treating diabetic peripheral neuropathy

This invention relates to a pharmaceutical composition and a health functional food for preventing or improving neurodegenerative disorders comprising mixed herb extracts ofandin a weight ratio of 3.5:1 (w/w). The herb extracts mixedandin a weight ratio of 3.5:1 have the synergetic effects on increasing the amount of nerve growth factor in vivo, increasing the neural cell proliferation, promoting the formation of neuritis and enhancing cognitive abilities. Thus, the herb extracts of the present invention may be used for a pharmaceutical composition and a health functional food for preventing or treating neurodegenerative disorders.

Composition comprising the extract of herbs for preventing or treating neurodegenerative disorders

Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb extract of a mixture of 3.5:1Rhizoma:(w/w). Having the ability to synergistically increase in vivo levels of nerve growth factor, compared to the extracts from the herbs alone or her mixtures of other weight ratios, the mixed herb extract is effective for preventing the apoptosis of nerve cells and promoting nerve regeneration. Thus, it can be applied to pharmaceutical compositions and health function foods preventive and curative of diabetic peripheral neuropathy.

Provided are biphenyl derivatives having the structure of Formula 1: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein Ris hydrogen, halogen, hydroxy, substituted or unsubstituted C-Calkyl, or C-Calkoxy; R, Rand Rare each independently hydrogen, halogen, substituted or unsubstituted amino, nitro, cyano, hydroxy, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkoxy, or &#x2014;C(O)R; Ris hydrogen or C-Calkyl; n is 0 or 1; and Ris hydrogen or amino, methods for preparing the same, and a pharmaceutical composition containing the same. The biphenyl derivatives having the structure of Formula 1 act as muscarinic M3 receptor antagonists, and thus are useful for the prevention or treatment of a disease selected from among chronic obstructive pulmonary disease, asthma, irritable bowel syndrome, urinary incontinence, rhinitis, spasmodic colitis, chronic cystitis, Alzheimer's disease, senile dementia, glaucoma, schizophrenia, gastroesophageal reflux disease, cardiac arrhythmia, and hyper-salivation syndromes.

Biphenyl derivatives and methods for preparing same

Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a pharmaceutically effective amount. The selective androgen receptor agonists according to the present invention act on androgen receptors to increase androgen activity, thereby being usefully applied as a therapeutic and prophylactic agent for diseases or conditions, of which symptoms may be improved or may respond to treatment by increased activities of androgen receptors, namely, a variety of hormone-related diseases in male and female, muscle wasting disorders, osteoporosis, etc.

Oxazolidine-based compound and selective androgen receptor agonist comprising same

The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition including the same as an active ingredient.

Tricyclic benzoxaborole compound, preparation method and use thereof

Disclosed are a novel oxazolidinone derivative exhibiting inhibitory activity against CETP, a preparation method thereof, and a pharmaceutical composition comprising the same. Exhibiting excellent inhibitory activity against CETP, the oxazolidinone derivative can be effectively applied to the prevention or treatment of various CETP enzyme activity- or HDL cholesterol level-related diseases such as dyslipidemia, atherosclerosis, and coronary heart disease.

Oxazolidinone derivative as CETP inhibitor, its preparation method, and pharmaceutical composition comprising the same

The present invention relates to a novel liquid composition comprised of piroxicam or its pharmaceutically acceptable salt (a non-steroid anti-inflammatory drug) and hyaluronic acid or its pharmaceutically acceptable salt (used for treatment of degenerative arthritis). Specifically, the invention provides a highly physicochemically stable liquid injection, comprising piroxicam and hyaluronic acid as active ingredients and &#x3b2;-cyclodextrin or its derivative and polyethylene glycol as additives to enhance its physicochemical stability, and the preparation method thereof.

Stable liquid pharmaceutical composition containing piroxicam or its pharmaceutically acceptable salt and hyaluronic acid or its pharmaceutically acceptable salt and the manufacturing method thereof

The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HTreceptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HTreceptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HTreceptors.

Benzamide derivatives

A method for preparing pyrazolopyrimidinone derivatives and their pharmaceutically acceptable salts having efficacy on the treatment of impotence, one of male sexual dysfunctions. The method comprises the steps of: a) chlorosulfonating a pyrazolamide compound to obtain a chlorosulfonated compound; b) reacting the chlorosulfonated compound of step (a) with a primary amine to obtain a sulfonamide compound and c) performing an intramolecular cyclization of the sulfonamide compound of step (b) to produce the compound of formula below 1, wherein the steps b) and c) are performed in situ in alcohol by adding a base to the reaction mixture without workup after the step b) is completed.

Preparing pyrazolopyrimidinone derivatives for the treatment of impotence

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Suwon-si, South Korea

Soon-Hoe Kim