Postech Academy-industry Foundation

Stemon Inc.

Soon Hag Kim

Jung Hwan Lee

Jong In Kim

Sung Ho Ryu

Hye Jung Lee

Sung Key Jang

Jong Hun Im

Young Chan Chae

Mi-Jin Kwon

Hyungu Kang

Ki Seok Kim

Youndong Kim

Sun Hak Lee

Eun Jung Jang

The present invention relates to a cell reprogramming method using a physical stimulation-mediated environmental influx, and more specifically, by subjecting differentiated or non-differentiated cells to physical stimulation which can promote an environmental influx, such as ultrasonic waves, laser or heat shock, without the introduction of a reprogramming-inducing factor or a chemical substance to the differentiated cells, the cells can be reprogrammed with just the imposition of an external environmental influx into pluripotent cells or arbitrary differentiated cells having a different expression type from the differentiated or non-differentiated cells, and as such an inducement has a simple and effective production process, the possibility of an autogenic cell therapy can be made greater.

Cell reprogramming method using physical stimulation-mediated environmental influx

Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.

Method of diagnosing cancer using a nucleolin specific aptamer

Method of treating hyperproliferation of cells using a nucleolin specific aptamer

Growing community of inventors

Seongnam-si, South Korea

Soon Hag Kim