Korea Institute of Science and Technology

Other

Soon Bang Kang

Youseung Kim

Seonhee Park

Jae Yang Kong

Gyo Chang Keum

Dae Young Jeong

Eunice Eun-Kyeong Kim

Min Seok Jang

Gyochang Keum

Youngsoo Kim

Dong Jin Kim

Ae Nim Pae

Kyung Il Choi

Yong Seo Cho

Hyunah Choo

Hee Sup Shin

Hyewhon Rhim

Sung Key Jang

Eun Joo Roh

Jae Kyun Lee

Yong Koo Kang

Seon Hee Seo

Kye Jung Shin

You Seung Kim

Key-Sun Kim

Hesson Chung

Ghilsoo Nam

Hee Sun Kim

Juhyeon Lee

Hye Jin Chung

Kee Dal Nam

Seon Hee Park

Hoh Gyu Hahn

Dong Yun Shin

Yoon Jee Kim

Woong Seo Park

Hye Ran Kim

Chan Seong Cheong

Cheolju Lee

Kee Hyun Choi

SeungGi Lee

Seonhec Park

Yousoung Kim

Eu Jin Ahn

Taeg-Su Jang

Suyeon Yeom

The present invention relates to oxazolidinone compounds represented by Chemical Formula 1, pharmaceutically acceptable salts thereof or hydrates, a method of preparing the same, and a pharmaceutical composition for preventing or treating Hepatitis C infection: 

Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same

Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof

Pyrrolidinone derivatives, their preparation and pharmaceutical composition comprising the same

Tetrahydropyridine derivatives acting on muscarinic acetylcholine receptors

There is disclosed a method for the preparation of pyrido benzoxazine derivative having the following formula I, that is improved in both production coat and yield. The method comprises reacting a compound of the following general formula II with tetraalkyl ammonium fluoride or with a mixture of tetraalkyl ammonium halide and metal fluoride in an organic solvent at a reaction temperature of about 30 to about 100.degree. C. for 1 to 3 hours under stirring; and reacting the resulting solution with a metal hydroxide or a metal carboxylate dissolved in water or in a mixture of water and alcohol, for 1 to 3 hours under heat. ##STR1## wherein X is a fluorine or chlorine atom and X.sub.1 and X.sub.2 each is a halogen atom or a nitro group, R is an alkyl group containing 1 to 4 carbon atoms and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is an alkyd group or allyl group containing 1 to 8 carbon atoms.

Method for the preparation of pyrido benzoxazine derivatives

A process for preparing (-)3(S)-methylbenzoxazine derivative of formula (I) comprising the steps of reacting the compound of formula (II) with benzoic acid, triphenylphosphine and diethyl azodicarboxylate in an organic solvent to obtain the compound of formula (III); hydrogenating the compound of formula (III) in the presence of a metallic catalyst to provide the compound of formula (IV); hydrolyzing the compound of formula (IV) to give the compound of formula (V); and reacting the compound of formula (V) with diethyl azodicarboxylate, triphenylphosphine, and zinc chloride in an organic solvent. The obtained (-)3(S)-methylbenzoxazine derivative is a useful intermediate for preparing an antibacterial agent which has a potent bacteriocidal effect. ##STR1##

Process for preparation of (-)3(S)-methylbenzoxazine derivative

There are disclosed (+)2-benzoyl-3-[prop-2(S)-yl)amino] acrylate derivatives of following the formula and a method for the preparation of the same; ##STR1## wherein X is a halogen; X.sub.1 and X.sub.2 are independently selected from a halogen and a nitro; and R and R.sub.1 each is an alkyl group containing 1 to 4 carbon atoms.

(+)2-benzoyl-3-[(prop-2(S)-yl)amino]acrylate derivatives and a method

There is disclosed a method for the preparation of the antibacterial (-) piperazine benzoxazine derivative having formula I comprising the steps of reacting (+)2-aminomethylene-3-oxo-3-phenylpropionate derivative of formula II with a base in an organic polar solvent, to give a (-) benzoxazine derivative of formula III: and reacting the (-) benzoxazine derivative of formula III with a piperazine derivative of formula IV in an organic polar solvent. ##STR1##

Method for the preparation of (-)piperazine benzoxazine derivatives

(+)2-benzoyl-3-(silyloxyprop-2(S)-yl)aminoacrylate derivative of following formula I which can be an useful starting material for producing a potent antibacterial compound and a method for the preparation of the same: ##STR1## wherein X is fluoro or chloro; X.sub.1 and X.sub.2 can be halogen or nitro; and R, R.sub.1, R.sub.2 and R.sub.3 each can be C.sub.1-8 alkyl group.

(+) 2-benzoyl-3-(silyloxyprop-2(S)-yl)aminoacrylate derivatives and a

There are disclosed 2-benzoyl-3-aminoacrylate derivatives of formula I and methods for the preparation of the same. The compounds can be used as starting materials to synthesize benzoxazine derivatives, potent antibacterial compounds. ##STR1##

2-nitrobenzoyl-3-silyloxyaminoacrylate derivatives and method for the

2-benzoyl-3-aminoacrylate derivatives of the following formula I and methods for the preparation of the same. ##STR1## wherein X is a halogen; X.sub.1 and X.sub.2 are independently selected from a halogen and a nitro; and R, R.sub.1 and R.sub.2 each is an alkyl group containing 1 to 4 carbon atoms. The compounds can be used as starting materials to synthesize benzoxazine derivatives, potent antibacterial compounds.

2-benzoyl-3-aminoacrylate derivatives and methods for the preparation of

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Soon Bang Kang