Bristol-Myers Squibb Compnay

California Institute of Technology

Soojin Kim

John E Macor

Suk Woo Nam

Fukang Yang

Guixue Yu

Jack Z Gougoutas

Chenkou Wei

Qi Gao

Michael J Humora

Mary F Malley

Sushil K Srivastava

Martha Davidovich

San Kiang

George R Gavalas

Kishta Katipally

Mark D Lindrud

Bruce T Lotz

Hyei-Jha Chung

Donald Kientzler

Yizhe Wang

Michael Tsapatsis

Margaret Gleeson

Fused pyridopyridazine inhibitors of cGMP phosphodiesterase

A novel apparatus and process for crystallizing submicron-sized crystals of a pharmaceutical composition. The submicron-sized crystals, which have an average size of less than 1 micron, provide high surface area end product crystals with greatly improved stability and purity, and which afford crystals having improved bioavailability, higher dissolution, decreased decomposition rate and longer shelf-life.

Sonic impinging jet crystallization apparatus and process

Methods of forming permselective oxide membranes that are highly selective to permeation of hydrogen by chemical deposition of reactants in the pore of porous tubes, such as Vycor.TM. glass or Al.sub.2 O.sub.3 tubes. The porous tubes have pores extending through the tube wall. The process involves forming a stream containing a first reactant of the formula RX.sub.n, wherein R is silicon, titanium, boron or aluminum, X is chlorine, bromine or iodine, and n is a number which is equal to the valence of R; and forming another stream containing water vapor as the second reactant. Both of the reactant streams are passed along either the outside or the inside surface of a porous tube and the streams react in the pores of the porous tube to form a nonporous layer of R-oxide in the pores. The membranes are formed by the hydrolysis of the respective halides. In another embodiment, the first reactant stream contains a first reactant having the formula SiH.sub.n Cl.sub.4-n where n is 1, 2 or 3; and the second reactant stream contains water vapor and oxygen. In still another embodiment the first reactant stream containing a first reactant selected from the group consisting of Cl.sub.3 SiOSiCl.sub.3, Cl.sub.3 SiOSiCl.sub.2 OSiCl.sub.3, and mixtures thereof and the second reactant stream contains water vapor. In still another embodiment, membrane formation is carried out by an alternating flow deposition method. This involves a sequence of cycles, each cycle comprising introduction of the halide-containing stream and allowance of a specific time for reaction followed by purge and flow of the water vapor containing stream for a specific length of time. In all embodiments the nonporous layers formed are selectively permeable to hydrogen.

Method for forming H2-permselective oxide membranes

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West Orange, NJ, United States of America

Soojin Kim