Korea Research Institute of Bioscience and Biotechnology

Soo Yong Kim

Kyung Seop Ahn

Sei Ryang Oh

Sang Ho Choi

Hyeong Kyu Lee

Ok-Kyoung Kwon

Jung Hee Kim

Ho Yong Park

Tae Sook Jeong

Mee-Young Lee

Hwa-Young Son

Kyoung-youl Lee

Zamora Villalobos Nelson

Katia Rosales-Ovares

Hwa Lee

Rodrigo Gamez-Lobo

Giselle Tomayo-Castillo

Rosales Ovares Kattia

The present invention relates to a cosmetic composition for preventing skin aging and reducing skin wrinkles containing an extract of-The cosmetic composition has an excellent antioxidant effect and exhibits the effect of inhibiting collagenase overexpression and increasing collagen gene expression, and thus can be effectively used for the purposes of preventing skin aging and reducing skin wrinkles.

Cosmetic composition for preventing skin aging and reducing skin wrinkles, comprising Viburnum stellato-tomentosum extract

Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-&#x3ba;B, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE, the expression of iNOS and COX-2, and the release of IL-1&#x3b2; and TNF-&#x3b1;, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.

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Daejeon, South Korea

Soo Yong Kim