Northwestern University

Soo Sung Kang

Richard B Silverman

Qing Jing

Dalton James Surmeier, Jr

Heng-Yen Wang

Garry Cooper

Yajuan Qin

Fengwei Zou

Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity.

Mammalian and bacterial nitric oxide synthase inhibitors

The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.

Selective calcium channel antagonists

Growing community of inventors

Evanston, IL, United States of America

Soo Sung Kang