Korea Institute of Science and Technology

Kist Corp.

Soo-Chang Song

Sun-Mi Lee

Sang Beom Lee

Youn Soo Sohn

Mi-Ran Park

Chang-Won Kim

Thrimoorthy Potta

Jang Il Kim

Bae Hoon Lee

Bae-Houn Lee

The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

Biodegradable and thermosensitive poly(organophosphazene) hydrogel, preparation method thereof and use thereof

The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (FeO, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for Tand T* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof

Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

Poly(organophosphazene) composition for biomaterials

A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.

Phosphazene hydrogels with chemical corss-link, preparation method thereof and use thereof

The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.

Thermosensitive polyphosphazene-bioactive molecule conjugates, preparation method thereof and use thereof

A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.

Poly(organophosphazene) hydrogels for drug delivery, preparation method thereof and use thereof

Disclosed are polyphosphazenes of Formula 1 showing a sol-gel behavior with a temperature change, a preparation method thereof, and injectable thermosensitive polyphosphazene hydrogels using the same 

Thermosensitive poly (organophosphazenes), preparation method thereof and injectable thermosensitive polyphosphazene hydrogels using the same

The present invention relates to novel cyclotriphosphazene derivatives represented by Formula (1) and a preparation method thereof wherein HNA is an amino acid group selected from glycine group(&mdash;NHCH COO ), aminomalonic acid group(&mdash;NHCH(COO ) ), aspartic acid group (&mdash;NHCH(CH COO )COO ) and glutamic acid group (&mdash;NHCH(CH CH COO )COO ), m is a repeating unit of poly(alkoxyethyleneglycol) selected from 2, 7, 12 and 16, and n is an integer representing number of alkyl carbons and selected from 0, 1, and 3.

Thermosensitive cyclotriphosphazene derivatives and a preparation method thereof

The present invention provides a novel thermosensitive cyclotriphosphazene-platinum complex conjugates represented by Formula 1,

Thermosensitive cyclotriphosphazene-platinum complex conjugate, its preparation method and anticancer agent containing the same

The present invention relates to novel biodegradable polyphosphazenes represented by Formula 1 and a preparation method thereof. Polyphosphazenes of the present invention not only have thermosensitivity and biodegradability simultaneously, but also their phase transition temperature and degradation rate can be controlled.

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Seoul, South Korea

Soo-Chang Song