Histogenics Corporation

The Brigham and Women's Hospital, Inc.

Ocugen, Inc.

Claesson, Hans Peter

Sonya Shortkroff

Laurence J B Tarrant

Robert Lane Smith

Hans P I Claesson

Eric J Roos

Hans Peter Ingemar Claesson

Kullervo Henrik Hynynen

Ferenc A Jolesz

Joseph B Khoury

R Lane Smith

Karoly Foldes

Carl Winalski

Joseph Khoury

Laurence J Tarrant

Hans P Claesson

Hans Peter Claesson

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.

Method for use of a double-structured tissue implant for treatment of tissue

Method for use of a double-structured tissue implant for treatment of tissue defects

A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.

A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.

Double-structured tissue implant and a method for preparation and use thereof

A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.

Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant

A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.

A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit.

The present invention describes methods for the treatment of joint diseases characterized by unwanted pannus, e.g., arthritis. The method involves the introduction of ultrasound energy into the inflamed cells or pannus of the joint to be treated resulting in destruction and/or modification of the pannus.

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Braintree, MA, United States of America

Sonya Shortkroff