Amylin Pharmaceuticals, Inc.

Gryphon Therapeutics, Inc.

Sonya Cressman

Stephen B H Kent

Paolo Botti

Christie L Hunter

Gerd G Kochendoerfer

Shiah-yun Chen

James A Bradburne

Donald W Low

Jill G Wilken

The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (FIG.D), and of pharmaceutical compositions that contain such proteins.

Polymer-modified synthetic proteins

The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG.). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.

Pseudo native chemical ligation

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Ladysmith, Canada

Sonya Cressman