Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Pharmed Artis Gmbh

University of Cape Town

Sonja Schiffer

Stefan Barth

Grit Hehmann-Titt

The technology provided herein relates to novel immunoproteases suitable to induce apotosis in selected diseased target cells, comprising the serine protease granzyme M, and methods for using such cytolytic fusion proteins for the treatment of various diseases, in particular for the treatment of cancer.

Immunoproteases

The present disclosure provides novel variants of enzymes exhibiting serine protease activity; nucleic acid molecules encoding said proteases, vectors, host cells containing the nucleic acids and methods for preparation and producing such enzymes; compositions and complexes comprising at least one of the proteases; and methods for using such enzymes as a part of an immunoprotease, in particular for the treatment of cancer.

Growing community of inventors

Juechen, Germany

Sonja Schiffer