Naicons S.r.l.

Fondazione Istituto Italiano Di Tecnologia

Vicuron Pharmaceuticals Inc.

Sonia Maffioli

Paolo Monciardini

Romeo Ciabatti

Gianbattista Panzone

Gianpaolo Candiani

Angelo Mario Reggiani

Mariacristina Brunati

Carlo Mazzetti

Marianna Iorio

Rosalia Bertorelli

Stefania Serina

Oscar Sasso

Anna Checchia

Stefano Donadio

Margherita Sosio

Bruno Catacchio

Gabriella Romano

Paola Guglierame

The present invention concerns novel lantipeptide (lanthionine-containing peptide) compounds having general formula (I), a process for their preparation, the key intermediates in said processes, their pharmaceutical acceptable salts and pharmaceutical compositions containing them, as well as their use in the treatment of pain.

Lantipeptide

The present invention concerns novel antibiotic compounds, which are lantibiotics, the processes for their preparation, their pharmaceutically acceptable salts, pharmaceutical compositions containing the lantibiotics, and their use as antibacterial agents. Compounds designated as lantibiotics, such as those of the present invention, are peptides belonging to the general class of antibiotic compounds, and are further generally characterized by the presence of the amino acids lanthionine and/or 3-methyllanthionine. The novel lantibiotic compounds are active against bacterial infections caused byspp.,spp,spp., and other bacteria.

Lantibiotic derivatives and process for their preparation

The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC&#x2014;CO&#x2014;R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH&#x2014; represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R&#x2014;COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.

Process for the production of ramoplanin-like amide derivatives

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Milan, Italy

Sonia Maffioli