University Court of the University of St. Andrews

University Court of the University of Dundee

Genase Therapeutics B.v.

Sonia Lain

Nicholas James Westwood

Martin Haraldsson

Ulrika Yngve

Lars Sandberg

Catherine Drummond

David Phillip Lane

Michael John Raymond Stark

Anna Rose McCarthy

Jonathan James Hollick

Ingeborg Van Leeuwen

David Philip Lane

Lars George Johansson

Lars Johansson

Federico Medda

There is herein provided a compound of formula I or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A, A, L, R, Rand n have meanings as provided in the description.

Tetrahydroindazoles and medical uses thereof

There is herein provided a compound of formula I (I) or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A, A, L, R, Rand n have meanings as provided in the description. 

The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar' are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases. 

Aroyl thiourea derivatives

The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions involving sirtuin function.

P53 activating compounds

The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar' is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano, thio, ester, acyl and amido; each Ris independently hydrogen, halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano and thio; and Ris as defined herein, or a physiologically acceptable salt, solvate, ester, amide or other physiologically functional derivative thereof. 

Pyrimidine derivatives and their pharmaceutical use

The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).

Growing community of inventors

Stockholm, Sweden

Sonia Lain