Merck Sharp + Dohme Corp.

Sonia Kerrad

Timothy Harrison

Duncan Edward Shaw

Ian Churcher

Martin Richard Teall

Alan John Nadin

Paul Joseph Oakley

Brian John Williams

Kevin Dinnell

Susannah Williams

Andrew Pate Owens

Jose Luis Castro Pineiro

Susannah William

Joanne Thomson

Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of &#x3b3;-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma-secretase

Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma secretase

Novel sulphones of formula I are disclosed:  The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones

Compounds of formula I: wherein Arand Arare optionally substituted aryl or heteroaryl, L is a bond, &#x2550;CH&#x2014; or &#x2014;(CHR)&#x2014;, and X is SCN, SR, S(O)R, (CRR)SOR, SON(R), SONHCOR, SONHN(R), OSON(R, OS(O)N(R), OSONHCOR, COR, NHCOR, NHCOR, NHCON(R), NHSORor NHSON(R), inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.

Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Compounds of formula I:inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

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Huningue, France

Sonia Kerrad