Beckman Coulter, Inc.

Beckman Instruments, Inc.

Songtai Tu

Duane G Barber

Richard P Watts

Steven D Mack

George K Shibata

Dang Minh Ngo

Paul J Ashton

Scott D Anderson

Christopher W Lindsey

A front-end system accepts samples and selectively provides aliquots of those samples to selected clinical chemistry analyzers coupled to the front-end system. The front-end system is coupled to an assembly of one or more clinical chemistry analyzers that might, for example, provide complementary analytical tools so that the overall system of front-end system and clinical chemistry analyzers provides a predetermined broad range of clinical analytical testing. The testing protocols for samples input to the overall system can be independently determined. Any sample may undergo a test within one or more of the clinical chemistry analyzers or a series of tests within a single or more typically within plural ones of the analyzers, depending upon the testing sequence defined in for that sample. The front-end system automatically identifies samples, draws aliquots, and transports the aliquots to the one or more clinical chemistry analyzers coupled to the front-end system. Sample identification, handling and testing are preferably automated A within the overall system to provide complex testing with reduced operator involvement. Consequently, the overall system may facilitate reduced operator costs and a reduced likelihood of errors in the routing and processing of samples.

Sample loading and handling interface to multiple chemistry analyzers

A workstation for integrating two or more automated analyzers. The workstation includes a sample rack handler assembly, having a single common sample rack input area for loading sample racks for the two or more automated analyzers, and a sample rack bypass area for passing sample racks to be processed by one of the two or more automated analyzers. The workstation also includes a sample aliquoting assembly, having a sample pipetter station for aliquoting samples into aliquot vessels for processing by another one of the two or more automated analyzers. The workstation further includes an internal shuttle for shuttling the sample racks between the sample rack input area, the sample rack bypass area, and the sample pipetter station, and an external shuttle for shuttling the sample racks between the sample rack input area, the sample rack bypass area, and the one of the two or more automated analyzers. In addition, the workstation includes a pick-and-place mechanism for transporting the aliquot vessels between the sample pipetter station and the other one of the two or more automated analyzers. A single common control console is provided for the workstation and the two or more automated analyzers.

Workstation for integrating automated chemical analyzers

A rate nephelometer of the type useful in automated chemical analyzers is provided. The nephelometer includes a laser for generating a polarized laser beam having an S-wave component and a P-wave component. The beam is split by a beam splitter specially constructed so that a known proportion of one of the two polarized portions of the beam is directed to a reaction container. In the reaction container, a first polarized component of the laser beam is used in a nephelometric chemical analysis. The remainder of the laser beam passes through the beam splitter to a laser control light detector. Before the remainder of the laser beam reaches the laser control light detector, however, the polarized component which is not used in nephelometric chemical analysis is filtered out. The laser control detector uses the non-filtered portion of the laser beam to control the output of the laser.

Rate nephelometer

A nephelometer and nephelometer/turbidimeter combination of the type useful in automated chemical analyzers is provided. The combination includes a laser for generating a polarized laser beam having an S-wave component and a P-wave component. The beam is split by a beam splitter specially constructed so that a known proportion of one of the two polarized portions of the beam is directed to a reaction container. In the reaction container, a first polarized component of the laser beam is used in a nephelometric chemical analysis. The remainder of the laser beam passes through the beam splitter to a laser control light detector. Before the remainder of the laser beam reaches the laser control light detector, however, the polarized component which is not used in nephelometric chemical analysis is filtered out. The laser control detector uses the non-filtered portion of the laser beam to control the output of the laser. The combination also includes an LED which emits a beam of light at a longer wave length than that of the laser. Such beam of light is projected through the reaction container to a turbidimeter light detector. A second beam splitter is provided between the reaction container and the turbidimeter light detector to deflect the residual portion of the laser beam away from the laser. This prevents the residual portion of the laser beam from being reflected back into the reaction container.

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Yorba Linda, CA, United States of America

Songtai Tu