Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Centaurus Biopharma Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

Song Tang

Fei Liu

Xiquan Zhang

Hongjiang Xu

Yizhong Zhu

Xin Tian

Hongmei Gu

Zhilin Chen

Weiwei Feng

Ling Yang

Shanchun Wang

Wei Shi

Yanlong Liu

Lulu Wang

Jianqiu Tang

Hongying Zhang

Bin Wang

Jinan Wang

Jianqing Zhang

Xujing Tang

Chao Gao

Bo Zhu

Jie Zhou

Yiyan Yao

Yang Li

Limin Liu

Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Trifluoromethyl-substituted sulfonamide as BCL-2-selective inhibitor

Disclosed are a crystal of a maleate of a compound of formula (I), a preparation method for the crystal, a crystallization composition of same, a pharmaceutical composition of same, and uses thereof in preventing and treating a tumor. 

Crystal of salt of quinazoline derivative

The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in the treatment of tumors, such as non-small cell lung cancer, breast cancer, and other malignant tumors. 

Salts of quinazoline derivative and method for preparing the same

The present invention provides a crystal of 6-arylamino pyridone carboxamide compound and a preparation method thereof. The crystal is obtained by dissolving 6-(2-chloro-4-iodophenylamino)-N-(2-hydroxylethyoxyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-carboxamide in an aprotic polar solvent and adding a second solvent thereto. The crystallization method has the advantage of simple and convenient operations, and is beneficial to an industrial production. The resulting crystal has the advantage a high purity and good stability, and is benefit to the manufacture and storage of a medicament containing the same.

6-aryl amino pyridone formamide compound crystal and preparation method therefor

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Lianyungang, China

Song Tang