H. Lee Moffitt Cancer Center and Research Institute, Inc.

Soner Altiok

Yin Xiong

Anthony M Magliocco

Farah K Khalil

Jasreman Dhillon

A method of distinguishing between lung squamous cell carcinoma and head and neck squamous cell carcinoma using a 22-gene biomarker signature is presented.

Method of distinguishing lung squamous cell carcinoma from head and neck squamous cell carcinoma

A method of distinguishing between urothelial carcinoma and squamous cell carcinoma of head and neck and lung primaries is presented. A 19-gene signature was developed which differentiates between metastatic urothelial carcinoma and squamous cell carcinoma in a metastatic site when the primary site is either known or unknown.

Method of distinguishing urothelial carcinoma from lung and head and neck squamous cell carcinoma

A method of determining disease diagnosis, progression and response to therapy through the use of xenograft animal models for determining cancer biomarkers is presented. In use, a tumor from a patient is transplanted into an animal model such as a mouse. Expression levels of biomarkers for a disease are assessed in the serum of the animal model. A personalized gene expression profile or biomarker gene signature may be obtained from the expression levels of the biomarkers which can be used to determine disease recurrence, progression and response to therapy.

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Tampa, FL, United States of America

Soner Altiok