Imam Mohammad Ibn Saud Islamic University

Sondos A J Almahmoud

Amin Osman Elzupir

A method of inhibiting a Programmed Cell Death Protein 1 (PD-1) or Programmed Death-Ligand 1 (PD-L1) protein includes reacting an N-(naphthyl)-ethylenediamine dihydrochloride (CHN·2HCl) with an aldehyde (R—CHO) in ethanol (CHCHOH) in the presence of sodium bicarbonate (NaHCO) to obtain a reaction mixture. The reaction mixture is then refluxed for 3 hours (h) to 7 h, yielding an aminoethyl Schiff base which is then contacted with PD-1 or PDL-1 protein to form a PD-1 or PDL-1 protein complex.

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Riyadh, Saudi Arabia

Sondos A J Almahmoud