Emulate, Inc.

Sonalee Barthakur

Josiah Daniel Sliz

Christopher David Hinojosa

Iosif Pediaditakis

Geraldine A Hamilton

Antonio Varone

S Jordan Kerns

Riccardo Barrile

Carolina Lucchesi

Gang Luo

Magdalena Kasendra

Hyoungshin Park

Sauveur Jeanty

Brian Zuckerman

Tanvi Shroff

Kyung-Jin Jang

Ananth Nookala

Ville Kujala

Donald Mckenzie

The invention generally relates to a microfluidic platforms or 'chips' for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.

Effects of space travel on human brain cells

The present invention contemplates compositions, devices and methods of simulating biological fluids in a fluidic device, including but not limited to a microfluidic chip. In one embodiment, fluid comprising a colloid under flow in a microfluidic chip has a fluid density or viscosity similar to a bodily fluid, e.g. blood, lymph, lung fluid, or the like. In one embodiment, a fluid is provided as a Theologically biomimetic blood surrogate or substitute for simulating physiological shear stress and cell dynamics in fluidic device, including but not limited to immune cells.

Rheologically biomimetic fluid surrogate

The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.

Microfluidic kidney-on-chip

Growing community of inventors

Boston, MA, United States of America

Sonalee Barthakur