Contipro A.s.

Sona Moravcikova

Vladimir Velebny

Radovan Buffa

Ivana Basarabova

Tomas Bobula

Petra Sedova

Pavlina Prochazkova

Hana Vagnerova

Iva Doleckova

The invention relates to the preparation of new polysaccharide derivatives comprising a double bond in the positions 4 and 5 of the pyranose cycle. The method of preparation consists in the oxidation of OH group in the position 6 to an aldehyde, followed by the elimination to form a double &#x2014;C&#x2550;C&#x2014; bond in the positions 4 and 5, and the final reduction of the aldehyde group in the position 6 into the original alcohol. The derivatives of polysaccharides prepared according to the invention show an enhanced antioxidant activity and some of them also a selective negative influence on carcinoma cell viability. (formula) where R represents &#x2014;NH&#x2014;CO&#x2014;CHor &#x2014;OH. 

Unsaturated derivatives of polysaccharides, method of preparation thereof and use thereof

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Jamne nad Orlici, Czechia

Sona Moravcikova