Amgen Inc.

Novartis Ag

Son C Tran

Sheldon B Moberg

Mark Dominis Holt

Francisca Tan-Malecki

Ronald Forster

Scott M Nunn

Ron Forster

Mutlu Karakelle

Xin Hong

Xiaoxiao Zhang

Myoung-Taek Choi

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

Method of assembling and filling a drug delivery device

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

An injector () may include a container () having a wall () with an interior surface () and a seal assembly () with an interior surface (), the interior surfaces () of the wall () and the seal assembly () defining a closed sterile reservoir () filled with a drug product. The injector () may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle () having a point () disposed only partially through the seal assembly () in a storage state, and disposed through the interior surface () of the seal assembly () into the sterile reservoir () in a delivery state. Further, the injection may include an actuator () that is adapted to move the container needle from the storage state to the delivery state.

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San Francisco, CA, United States of America

Son C Tran