Other

Harvard College

Son C Nguyen

Chao-ting Wu

George M Church

Evan R Daugharthy

Jeff Maynard

The present invention relates to a method of identifying a target genomic nucleic acid sequence including hybridizing a set of probes to the target genomic nucleic acid sequence, wherein the set of probes has a unique associated barcode sequence for identification of the target genomic nucleic acid sequence, wherein each probe of the set includes (1) a complementary sequence complementary to a first strand of the target genomic nucleic acid sequence and (2) the associated barcode sequence or a portion of the associated barcode sequence, sequencing the associated barcode sequence from probes hybridized to the target genomic nucleic acid sequence using a fluorescence-based sequencing method, and identifying the target genomic nucleic acid sequence by the sequenced barcode sequence.

Methods for detecting and identifying genomic nucleic acids

The present invention relates to a method of covalently attaching a chromosome within a cell to a matrix including modifying a plurality of nucleotides within the chromosome to include a matrix attachment moiety wherein the chromosome contacts the matrix, and attaching the matrix attachment moiety of the plurality of nucleotides to the matrix, thereby attaching the chromosome to the matrix.

Methods for attaching cellular constituents to a matrix

A system/method to store and compare computer generated vector lines through an insecure or a secure communication channel. Using an input device (i.e. computer Keyboard, finger, soft keypad, or any other input from body movements, electrical current, or impulses, or input from human or mechanical sound waves) to a physical machine, or through a token (i.e. credit card, USB token, which can be carried around by user), a user enters and sends their unique identifier and reference code (i.e. PIN, password, other secret code) to the physical machine by making a contact or contact-less to the computer system. As part of the enrollment process the user inscribes a pre-determined set of continuous vector lines (CVLs). The CVLs include data points that are collected from any computer pointing device in a specific format, using a push down anatomical technique and are sent to local active content (i.e. a library, or a program, or an add-on to the internet browser i.e. ActiveX) or a remote server for further analysis of the two CVLs. A user should go through an Enrollment and Verification process to capture the data points and this process uses a two factor authentication and a verification scheme. The collected data points that represent a CVL profile made previously is kept in a database, registry, or memory that can be encrypted and accessed (locally or remotely) by using a reference number or other unique identifier to enable the comparison of a newly generated CVL identifier to the previously generated one.

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West Roxbury, MA, United States of America

Son C Nguyen