Novartis Ag

Sandoz Pharm. Corp.

Novartis Pharmaceuticals Corporation

Sompong Wattanasin

Faizulla G Kathawala

Richard William Versace

Rainer Albert

Claus Ehrhardt

David Thomas Parker

Kenneth Walter Bair

Frederick Ray Kinder, Jr

Gabriele Weitz-Schmidt

Christopher Turchik Jagoe

Karl Welzenbach

Peter Josef Von Matt

Goetz E Hardtmann

Prasad Koteswara Kapa

Paul L Anderson

Leslie Wighton McQuire

Benjamin B Mugrage

Lauren Gilchrist Monovich

Joerg Kallen

Josef Gottfried Meingassner

Ulrich Hommel

Roger A Fujimoto

Jerome Linder

Francois Lenoir

George T Lee

Yunshan Peng

Nicholas A Paolella

Kau-Ming Chen

Grazia Piizzi

John H VanDuzer

Janet Dawson

Didier Roche

Markus Rolf Dobler

The present application describes organic compounds of a general formula: 

Organic compounds and their uses

Certain phenylacetic acids and derivatives

Diazacycloalkanedione derivatives

The present invention relates to certain substituted caprolactam compounds, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.

Use of certain substituted caprolactams in treating tumors

VLA-4 antagonists

Substituted 2-oxo-1,4-diazacycloalkanes

The present invention relates to certain substituted caprolactam compounds of formula (I), where R,is (C,)alkyl or (C,)cycloalkyl; R,hydrogen or (C,)alkyl; X is (C,)alkynylene; (C,)alkynylene; m is 0 or 1; and R,is (C,)cycloalkyl; or an aromatic ring system selected from (II, III, IV and V), where R,is hydrogen, chloro, or methoxy; R,is hydrogen, chloro, (C,)alkyl or (C,)alkoxy, and Z is oxygen, sulfur, N&mdash;H, or N&mdash;CH,; or a pharmaceutically acceptable acid addition salt thereof, where possible, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.

Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation

Quinoline analogs of mevalonolactone of the following formula are useful as anti-cholesterol synthesis agents: ##STR1## where the substituents are as defined in the specification.

Quinoline analogs of mevalonolactone and derivatives thereof

Compounds of the formula ##STR1## the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

Idene analogs of mevalonolactone and derivatives thereof

Compounds of the formula I: ##STR1## wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom;

Azaindole derivatives useful as cholesterol biosynthesis inhibitors

Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P.sub.1 is independently an hydroxy group-protecting group, and

Processes for the synthesis of diprotected

Growing community of inventors

Hopatcong, NJ, United States of America

Sompong Wattanasin