The University of Western Ontario

Lanxess International Sa

Polyanalytik Inc.

Arlanxeo Deutschland Gmbh

Arlanxeo Canada Inc.

Solmaz Karamdoust

Dana K Adkinson

Lorenzo Ferrari

Elizabeth R Gillies

Amer Ebied

Goran Stojcevic

Eric D Landry

Collin V Bonduelle

Peng Xiang

Lorenzo P Ferrari

In general, this invention discloses methods for extracting and analyzing coatings from implanted and excised animal tissue medical devices; wherein the coating comprises at least one biodegradable polymer and at least one or more therapeutic ingredients. The present invention describes optimal conditions for extraction and isolation of biodegradable polymers and therapeutics in medical devices or complex pharmaceutical agent formulations prior and after implanting or injecting into animal tissues. Particularly this work relates to accurate isolation and quantification of ppm amounts of polymer and/or therapeutics without biological interferences. The use of GPC/SEC systems equipped with light scattering detectors enables 'absolute' or “true” molecular weight determination. All of these improvements allow for accurate determination of the degradation profile of the polymer/therapeutic component independent of polymer standards used in conventional GPC/SEC.

Methods for extracting and analyzing compounds from implanted and excised medical devices

The present invention relates to novel graft copolymers of functionalized poly(isoolefin-co-conjugated diolefin, and a process of preparing such graft copolymers. The present invention also relates to a method of preparing functionalized copolymers of isoolefins and conjugated diolefins.

Methods for preparation of novel graft copolymers

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London, Canada

Solmaz Karamdoust