Aveo Pharmaceuticals, Inc.

Solly Weiler

William M Winston, Jr

Jeno Gyuris

Ting Chen

Kristan Meetze

Lyne Breault

Zhigang Weng

Lorena Lerner

Sylvie Vincent

Steve Bottega

Qing Liu

Ailin Bai

Maria Isabel Chiu

Laura L Poling

Sandra Abbott

Steven Tyler

Nianjun Tao

Fang Wang

Michael DePrima

Christina Fleet

Jin-Kyeung Woo

May Han

Kerry Whalen

Andrea Boudrow

James Gifford

Jinwei Jiang

Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.

Anti-GDF-15 antibodies

Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.

Anti-ErbB3 antibodies

Anti-GDF15 antibodies

Anti-ERBB3 antibodies

Methods of treatment using anti-GDF15 antibodies

Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.

Anti-ron antibodies

Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d' Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.

Anti-RON antibodies

Monoclonal antibodies that bind and inhibit biological activities of human FGFR2 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation or overexpression of FGFR2.

Anti-FGFR2 antibodies

Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.

Fibroblast growth factor receptor 3 (FGFR3) binding proteins

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Newton, MA, United States of America

Solly Weiler