Midatech Limited

Centro De Investigacion Cooperativa En Biomateriales (cic Biomagune)

Centro De Investigacion Cooperative En Biomateriales (cic Biomagune)

Soledad Penades Ullate

Thomas William Rademacher

Rafael Ojeda Martinez De Castilla

Elena Martines

Isabel Garcia Martin

Gottfried Himmler

Ralf Kircheis

G C Mudde

Manuel Martin Lomas

Jose Luis De Paz Carrera

Africa Garcia Barrientes

Godfrey Bradman

Geert C Mudde

T Midatech Limited Rademacher

Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.

Nanoparticles comprising antigens and adjuvants, and immunogenic structures

Materials and Methods are disclosed for producing nanoparticles linked to antibacterial ligands, including antibiotics and/or molecules which bind to bacterial markers, and for the use of the nanoparticles for the treatment of conditions treatable by the antibiotic ligands.

Nanoparticles comprising antibacterial ligands

The present invention provides a container and a method that can be used to transport and store AFM probes in a liquid buffer. This container fastens an AFM probe and consists of a plastic lid that secures a probe while keeping it in a controlled environment, thus preventing that the tips are contaminated by air-borne molecules, packaging material, deposited substances or air bubbles. In the case of functionalized probes, the surface molecules are still functional upon arrival. The tips cannot be broken upon transport because they are held by the container, however the probes can be easily removed upon opening of the container.

Liquid-tight container for storing and transporting AFM probes

The present invention includes an apparatus that holds the probes to a solid support throughout the passages of the functionalization process, thus avoiding user-dependent breakage or damage of the fragile AFM cantilevers. The apparatus allows the tips of the AFM probes to be placed face-down, which avoids the deposition of contaminants on their functional side. The device also allows functionalizing the tips with small liquid volumes and cleaning. The present invention includes a functionalization process preventing non-specific adsorption of molecules on the tip.

Apparatus and method for the functionalisation of AFM tips

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San Sebastian, Spain

Soledad Penades Ullate