New York Medical College

USA As Represented by Secretary of the Navy

Suntory Limited

Soldano Ferrone

Suresh C Srivastava

Masashi Matsui

Rashid A Fawwaz

The invention concerns murine antiidiotypic monoclonal antibodies which are the internal image of determinants recognized by a monoclonal antibody on high molecular weight-melanoma associated antigen (HMW-MAA), antibody derivatives, hybridoma cell lines secreting such antiidiotypic monoclonal antibodies, and processes for the preparation of such antiidiotypic monoclonal antibodies, of their derivatives and of the hybridoma cell lines. The murine antiidiotypic monoclonal antibodies are useful for the determination of antibodies directed against high molecular weight-melanoma associated antigen, for the modulation of the immune response to HMW-MAA and for the treatment of melanoma.

Antidiotypic monoclonal antibodies for treatment of melanoma

Antiidiotypic monoclonal antibodies MK2-23 anti-melanomal antibody 763.74

Specific antibody of the invention is capable of differentiating between malignant and benign tumors, and is obtained by culturing hybridoma cells prepared from tumor cells treated with a certain anti-tumor substance.

Monoclonal antibody

Palladium-109, a beta-emitting radionuclide, when chelated to anti-melanoma monoclonal antibody demonstrates high uptake in melanoma and thus is useful for tumor therapy.

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Scarsdale, NY, United States of America

Soldano Ferrone