Roussel Uclaf

Solange G D'Ambrieres

Jean-Francois Chantot

Jozsef Aszodi

Jean-Georges Teutsch

Alexis Denis

Constantin Agouridas

Daniel Humbert

Patrick Fauveau

Christophe Dini

Daniel Hunbert

Odile L Martret

An erythromycin compound of Formula I or its non-toxic acid addition salt having antibiotic activity.

Erythromycin compounds

A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula ##STR1## syn isomer, in the (R) or (S) form or in the form of an (R,S) mixture, in the form of an internal salt or their salts with organic or mineral acids, wherein the variables are herein below defined, having antibacterial properties.

Cephalosporins

A compound selected from the group consisting of a syn isomer of a compound of the formula: ##STR1## in the R or S form or in the form of an R, S mixture wherein the variables are herein below defined, and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.

The syn isomer of a compound of the formula ##STR1## in the R or S form or a mixture of R and S forms wherein selected from the group consisting of ##STR2## and their non-toxic, pharmaceutically acceptable acid addition salts wherein the substituents are defined as in the specification having antibacterial activity and their preparation.

A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## in the R or S form or in the form of an R, S mixture wherein R.sub.1, Rc, Rb, A and A' are defined as in the following specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.

A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## in the R or S form or in the form of a R, S mixture wherein the various substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.

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Solange G D'Ambrieres