University of California

Tel Hashomer Medical Research Infrastructure and Services Ltd.

Sol Kimel

Michael W Berns

J Stuart Nelson

Arie Orenstein

Genady Kostenich

Lars Othar Svaasand

Eliahu Pewzner

Reuben Achiron

Disclosed are methods and devices comprising an elongated probe for the in vivo detection of meconium in amniotic fluid held in an amniotic sac based on detecting the presence of Zinc-coproporphyrin I (ZnCP). ZnCP is excited at approximately 405 nm and emits characteristic fluorescence, centered at about 580 nm and less intensely at 630 nm.

Device and method for identification of meconium in amniotic fluid

The invention is a technique for dynamic measurements of the heat transfer coefficient to the outer layer of the skin surface using a high thermal conductivity metal in an insulating block as the standardized target. The coefficient is dependent on the specific design of the cryogen valve and nozzle, and values up to 11 500 W/m K values were measured for a 100 ms long spurts. The values for longer spurts are dependent on air humidity, as ice/snow formation then tends to form a thermally insulating layer. The average value of the heat transfer coefficient for a 200 ms long spurt was determined to 8000 W/m K for conditions of normal room humidity and temperature. The technique enables an improved prediction of the temperature profile and cooling efficiency during therapy, and may thereby contribute to an improved therapeutic outcome.

Method and apparatus for measuring the heat transfer coefficient during cryogen spray cooling of tissue

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Haifa, Israel

Sol Kimel