Celanese Gmbh

Other

Celgene Corporation

National Patent Development Corporation

Sol J Barer

Richard F Stockel

Jih-Han Hsieh

Peter C Maxwell

Peter Carl Valenti

Jerome B Zeldis

Anthony J East

Andrew L Zeitlin

Michael M Besso

Jaroslav Vit

Henry H George, Jr

Charles L Smart

Henry A Terwedow, Jr

Patti L Kostrzewski

Michael Marchwinski

Scott R Hagedorn

This invention relates to compositions comprising thalidomide and another anti-cancer drug which can be used in the treatment or prevention of cancer. Preferred anti-cancer drugs are topoisomerase inhibitors. A particular composition comprises thalidomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, and irinotecan. The invention also relates to methods of treating or preventing cancer which comprise the administration of a thalidomide and another anti-cancer drug to a patient in need of such treatment or prevention. The invention further relates to methods of reducing or avoiding adverse side effects associated with the administration of chemotherapy or radiation therapy which comprise the administration of thalidomide to a patient in need of such reduction or avoidance.

Compositions and methods for the treatment of cancer

This invention provides hexamethylenediamine muconate salt. This novel salt can be produced by bioconversion of toluene to muconic acid in the presence of hexamethylenediamine. Hydrogenation of this salt provides hexamethylenediamine adipate salt.

Production of hexamethylenediamine muconate salt

This invention provides a process for the bioconversion of a non-growth aromatic feed to an accumulated quantity of a picolinic acid product with reduced accumulation of 2-hydroxymuconic semialdehyde, and conducted in the presence of ammonium or a primary amine, which acid subsequently can be converted by chemical means to a pyridine product.

Production of picolinic acid and pyridine products via pseudomonas

This invention provides a process for producing nylon 6,6 salt which involves bioconversion of toluene to muconic acid in the presence of hexamethylenediamine to yield hexamethylenediamine muconate salt. Hydrogenation of this salt provides an aqueous solution of the desired hexamethylenediamine adipate salt.

Production of nylon 6,6 salt

This invention provides an improved fermentation process for bioconversion of toluene to muconic acid. The process involves operating the bioconversion system under phosphate-limiting conditions so as to achieve an increase in specific muconic acid productivity with a stabilized population of microorganism such as an ATCC No. 31,916 type of Pseudomonas putida Biotype A mutant strain.

Muconic acid productivity by a stabilized mutant microorganism population

Selected substituted phenols may be usefully employed as mosquito development inhibitors.

Mosquito development inhibitor employing substituted phenols

The present invention provides a protective garment fabric material for enhanced personal protection against harmful substances present in the ambient atmosphere. This fabric is manufactured from microporous hollow fibers containing neutralization agents capable of detoxifying chemical or biological agents in the lumina of the fibers. The protective fabrics of the present invention possess enhanced mechanical strength, high efficiency, and at the same time provide a larger concentration of detoxicant per surface area than the protective fabrics of the prior art.

Microporous hollow fibers as protectants against toxic agents

Enhancement of biological effectiveness of carbamate insecticide compositions with alkanediols.

Insecticidal compositions

A chemical pruning, and contact composition for the selective inhibition of suckering in plant species subject thereto, particularly tobacco, said composition comprising as an active species 2-butyl-2-ethyl-1,3-propanediol.

2-Butyl-2-ethyl-1,3-propanediol as a chemical pinching agent

A chemical pruning, and contact composition for the selective inhibition of suckering in plant species subject thereto, particularly tobacco, said composition comprising as an active species 2-ethyl-1,3-hexanediol.

2-Ethyl-1,3-hexanediol as a chemical pinching agent

N-chloro chloroalkanamides or chloro hydrocarbyl substituted alkanamides of the formula ##STR1## where R.sub.1 is hydrogen or alkyl of 1 to 6 carbon atoms, R.sub.4 is alkylene or chloroalkylene of 1 to 5 carbon atoms, n is 0 or 1, R.sub.2 and R.sub.3 are hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, alkaryl of up to 8 carbon atoms or aryl of up to 8 carbon atoms, have been found useful as herbicides. Preferably n is 0 and R.sub.2 and R.sub.3 are hydrogen chlorine, phenyl or alkyl or 1 to 2 carbon atoms. Most preferably R.sub.2 and R.sub.3 are hydrogen or chlorine.

N-chloro-chloroacetamides as herbicides

Antifungal compositions incorporating 1,4-butanediol bis(chloroacetate), and methods for combatting fungal infestation, especially in agriculture.

Antifungal compositions of butanediol bis (chloroacetate)

Compounds of the formula ##STR1## wherein Y is chlorinated alkyl of 1 to 6 carbon atoms; wherein R is C.sub.n H.sub.2n or R.sub.2 C.sub.n H.sub.2n-1 wherein n is an integer of 1 to 11 and R.sub.2 is aralkyl or carboxyalky; and wherein R' is hydrogen, alkyl, haloalkyl, alkaryl or aryl; have fungicidal activity. The compounds can be used in the free acid or salt form.

Halogenated acylamino acids as fungicides

Chemical pruning, and contact compositions for the selective inhibition of suckering in plant species subject thereto, particularly tobacco, said compositions comprising as an active species a lower alkane diol, especially 1,3-butanediol.

Growing community of inventors

Fanwood, NJ, United States of America

Sol J Barer