Meiji Seika Kaisha, Ltd.

Koichi Shudo

Sojiro Shiokawa

Satoshi Yoshida

Hiroshi Murakami

Yasuo Sato

Yasuo Yamamoto

Takumi Takeyasu

Osami Takenouchi

Masaaki Izumi

Yumiko Yanagisawa

Tomoko Ito

Hidenori Kasai

Tetsutaro Niisato

Kenzo Hariyama

A compound represented by the following general formula (1): wherein Rrepresents a halogen atom, Rrepresents hydrogen atom or a lower alkyl group, and Rrepresents hydrogen atom, a lower alkyl group, a lower alkoxyl group, a hydroxy lower alkyl group, a halogen atom, or a substituted or unsubstituted amino group, wherein a substituent on the amino group is selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkylcarbonyl group, and an amino protective group, or a salt thereof. The compound of the present invention or a salt thereof is useful as an active ingredient of medicaments for preventive and/or therapeutic treatment of conditions of irritable bowel syndrome and digestive tract functional disorder, or condition of diarrhea.

Benzoxazole derivatives and drugs containing the same as the active ingredient

According to this invention, there is provided an indole derivative having the general formula (I)wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) Rand Reach stand for a hydrogen atom or an alkyl group, independently, or (ii) Rand Ras taken together form a cycloalkyl group or an aromatic ring, or (iii) Rand Ras taken together form a heterocyclic ring, and Ris a hydrogen atom, a (C-C)alkyl group or others, Ris a substituted alkyl group and Ris a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.

Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof

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Yokohama, Japan

Sojiro Shiokawa