Bristol-myers Squibb Compnay

Bristol-myers Company

Soichiro Toda

Takayuki Naito

Haruhiro Yamashita

Yuji Nishiyama

Toshikazu Oki

Koji Tomita

Susumu Nakagawa

Yasutaro Hamagishi

Satoshi Yamamoto

Osamu Tenmyo

Takashi Tsuno

Mary P Rosser

Toshifumi Hasegawa

This invention relates to novel elsamicin A derivatives wherein the 2'-amino group is selectively modified by acylation or alkylation, a process for producing said elsamicin A derivatives, an antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.

Chemical modification of 2'-amino group in elsamicin a

Disclosed is a novel compound, designated BU-4514N, which is produced by cultivation of a novel strain of Microtetraspora, designated species T689-92. The novel compound possesses antibacterial and neuritogenic properties.

Compound produced by a strain of microtetraspora having antibacterial

This invention relates to elsamicin A derivatives wherein the 2'-amino group is selectively modified by acylation or alkylation, a process for producing said elsamicin A derivatives, an antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.

Chemical modification of 2'-amino group in elsamicin A

This invention relates to novel elsamicin A derivatives having an alkylidene group on the 3' and 4'-OH group or a tetrahydropyranyl group on the 4'-OH group, a process for producing said elsamicin A derivatives, antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.

Chemical modification of elsamicin A at the 3' and/or 4' OH groups

Disclosed herein are antibiotic BU-4164E A and B isolated from Streptomyces sp. These compounds are prolyl endopeptidase inhibitors.

BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of

BU-4164E - A and B, prolyl endopeptidase inhibitors

1-N-(.omega.-Amino-.alpha.-hydroxyalkanoyl) derivatives of 4'-deoxy-6'-N-methylkanamycin A are prepared by multi-step processes beginning with 1,3-ureidokanamycin A. The compounds are potent antibacterial agents.

1-N-(.omega.-amino-.alpha.-hydroxyalkanoyl) derivatives of

3'-Deoxybutirosin A (3'-deoxyambutyrosin A), which is prepared from butirosin A, possesses an improved antibacterial spectra, especially against butirosin A resistant organisms.

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Ohmiya, Japan

Soichiro Toda