Kyowa Hakko Kogyo Co., Ltd.

Soichiro Sato

Fumio Suzuki

Yoshisuke Nakasato

Kenji Ohmori

Tadafumi Tamura

Katsushige Gomi

Etsuo Ohshima

Michio Ichimura

Haruhiko Manabe

Nobuo Kosaka

Kyoichiro Iida

Hidee Ishii

Takashi Kawakita

Hiroshi Tsumuki

Koji Yanagawa

Hiroshi Nakajima

Tohru Matsuzaki

Rie Koike

Hiroshi Tanaka

Kenji Shibata

Hiroyuki Ishida

Motoo Yamasaki

Masaji Kasai

Hiromitsu Saito

Tadashi Ashizawa

Tatsuya Tamaoki

Haruki Takai

Masami Okabe

Joji Nakamura

Daisuke Machii

Koji Suzuki

Uichiro Kimura

Junji Kanazawa

Masako Uchii

Masako Hamada

Shun-Ichi Ikeda

Kimihito Sasaki

Etsuko Nukui

Tomomi Sugiyama

Hisakatsu Seo

Derivatives of benzofuran or benzodioxazole compounds

Derivatives of benzofuran or benzodioxole

The present invention relates to compounds represented by formula (I): ##STR1## wherein Z represents Gly or Cys; X represents an (.alpha.-amino acid residue; Y represents a natural calcitonin moiety, a partial natural calcitonin peptide moiety, or a natural calcitonin-like peptide moiety; m represents an integer of 5-8, .alpha.-amino acid residues represented by X being the same or different; and n represents an integer of 0-3; provided that when m is 5, the sequence of 4 C-terminal residues of --(X).sub.m -- is different from the sequence of the third to sixth amino acids of natural calcitonin, and pharmaceutically acceptable salts thereof.

Calcitonin derivatives

The present invention relates to propenone derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR.sup.5 (wherein Y represents S or O; and R.sup.5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R.sup.2 and R.sup.3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R.sup.2 and R.sup.3 are combined to form substituted or unsubstituted methylene or ethylene; R.sup.4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.

Propenone derivatives

The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, --O--(CH.sub.2).sub.n --OR.sup.5, or ##STR2## R.sup.3 represents hydrogen, lower alkyl, or ##STR3## R.sup.4 represents hydroxy, lower alkoxy, substituted or unsubstituted aryloxy, or --NR.sup.10 R.sup.11, and X represents CO or SO.sub.2, with the proviso that when R.sup.3 is hydrogen or lower alkyl, and X is CO, R.sup.4 is --NR.sup.10 R.sup.11, or pharmaceutically acceptable salts thereof.

Indole derivatives

Tetracyclic compound

Pyrazolothiazolopyrimidine derivatives

Tetracyclic compounds

Growing community of inventors

Mishima, Japan

Soichiro Sato