Japan Science and Technology Agency

National Institute of Advanced Industrial Science and Technology

National Institute for Materials Science

National Institute for Materials

Soichiro Itoh

Junzo Tanaka

Masanori Kikuchi

Kenichi Shinomiya

Toshimasa Uemura

Tetsuya Tateishi

Shinichi Sotome

This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant. The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability. Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.

Process for producing porous composite materials

Disclosed is an artificial vertebra having a bone-marrow regenerating function, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of the HAp particles along the Col fiber. The HAp/Col composite body is formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto. The present invention also provides a biodecomposable/bioabsorbable support for fixing an artificial vertebra, comprising a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding the injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction. The plate has four corner regions each formed with a screw hole for fixing the plate to vertebral bodies.

Artificial pyramid

Growing community of inventors

Tokyo, Japan

Soichiro Itoh