Kowa Company Limited

Soichi Oda

Seiichi Sato

Hiroyuki Ishiwata

Mototsugu Kabeya

Makoto Suda

Manabu Shibasaki

Hiroshi Nakao

Takao Nagoya

Yukio Hattori

Masami Shiratsuchi

Yukiyoshi Yamazaki

Hiromichi Shigyo

Ayumu Okuda

Masahiro Nishikawa

Tsutomu Toma

Kazutoyo Abe

Hidefumi Ozawa

Takaaki Araki

Yoshinori Kyotani

Takahiro Kitamura

Takayuki Matsuda

Masao Ohkuchi

Hideo Yoshizaki

Tomoyuki Koshi

Kyoko Kotaki

Yuriko Habata

A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Bis(5-aryl-2-pyridyl) derivatives

A compound represented by the following formula (1): (wherein each of Rand R, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R, R, R, and R, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a Calkyl group, a trifluoromethyl group, a Calkoxy group, a Calkylcarbonyloxy group, a di-Calkylamino group, a Calkylsulfonyloxy group, a Calkylsulfonyl group, a Calkylsulfinyl group, or a Calkylthio group, or Rand R, or Rand Rmay be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N&#x2014;R(Rrepresents a hydrogen atom, a Calkyl group, a Calkylsulfonyl group, or a Calkyloxycarbonyl group); Y represents an oxygen atom, S(O)(l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.

PPAR-activating compound and pharmaceutical composition comprising the compound

A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR&#x3b1;.

A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof:wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4):wherein, in formula (2), Ris a hydrogen atom or a di(lower alkyl)amino(lower alkyl) group, and m is an integer of 1 or 2; in formula (3), Yand Yeach is a nitrogen atom or a CH group, and n is 0 or an integer of 1 to 6; in formula (4), Rand Reach is a hydrogen atom or a lower alkyl group, Z represents a single bond, a substituted methylene group, a substituted imino group, an oxygen atom or a cycloalkylene group, and p and q each is 0 or an integer of 1 to 6.

Bis(2-aryl-5-pyridyl) derivatives

Diamide compound and medicine containing the same

Preparation process of biphenylcarboxylic acid amide derivatives

Benzoxazole compound and pharmaceutical composition containing the same

Cyclic amide compound

Diamide compounds and compositions containing the same

Cyclic amide compounds

Pyridazine derivatives and drugs containing the same as the active ingredient

Diamide compound and drugs containing the same

The present invention relates to compounds represented by the following general formula (1):

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Higashimurayama, Japan

Soichi Oda