National University of Singapore

Osteopore International Pte Ltd

Osteopore Korea Co. Ltd

Soi Khoon Yew

Swee Hin Teoh

Hae-Ryong Song

Joon Ho Wang

Ji Hoon Bae

Kelvin Hong Yap Koh

Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.

Resorbable scaffolds for bone repair and long bone tissue engineering

Growing community of inventors

Singapore, Singapore

Soi Khoon Yew