Memorial Sloan Kettering Cancer Center

Sohn Kim

Eric G Pamer

Peter McKenney

Silvia Caballero

Simone Becattini

The present disclosure relates to novel lantibiotics, lantibiotic pharmaceutical compositions, isolated and recombinant lantibiotic-producing bacteria, bacterial pharmaceutical compositions, methods of producing novel lantibiotics from lantibiotic-producing bacteria, and methods of using such lantibiotics, lantibiotic pharmaceutical compositions, and bacterial pharmaceutical compositions to treat gram-positive bacteria infections, including vancomycin resistant enterococci infections, in patients, and to treat food and other objects to avoid gram-positive bacteria contamination.

Lantibiotics, lantibiotic-producing bacteria, compositions and methods of production and use thereof

The disclosure relates to a therapeutic composition for treatinginfection orcolonization, the composition including at least one, at least two, at least three, or all of an isolatedbacteria, an isolatedbacteria, an isolatedbacteria, and/or an isolatedbacteria in a formulation suitable for administration to a subject. The disclosure further provides similar compositions lacking an isolatedbacteria. The disclosure additionally provides methods of treatinginfection or colonization using such compositions.

Growing community of inventors

New York, NY, United States of America

Sohn Kim