Fujifilm Corporation

Sohichiro Nakamura

Ryusuke Osaki

Sho Onozawa

Heijiro Hirayama

Masayuki Naya

Takafumi Noguchi

Katsuhiro Ishii

Kenichi Hamada

Yuki Sato

Akihiro Asakura

Provided is an optical measurement device capable of easily measuring a scattering intensity at different scattering angles or different wavelengths. An optical measurement device with a low-coherence interferometer includes a detection unit having at least one of a first detection unit that detects an interference light intensity per wavelength by means of interference between at least a part of scattered light obtained by allowing incident light to be incident on a dispersion liquid including particles and reference light or a second detection unit that detects an interference light intensity per scattering angle by means of interference between at least a part of the scattered light obtained by allowing the incident light to be incident on the dispersion liquid including the particles and the reference light, and a conversion unit extracts a scattering intensity at a specific depth and a specific wavelength of the dispersion liquid from data of the interference light intensity per wavelength detected by the first detection unit or a scattering intensity at a specific depth and a specific scattering angle of the dispersion liquid from data of the interference light intensity per scattering angle detected by the second detection unit and converts data of the extracted scattering intensity into time fluctuation data of the scattered light at the specific depth of the dispersion liquid.

Optical measurement device

Pixels of a mask image with which a target object is irradiated are shifted by a determined distance by sequentially turning on one light emission point or two or more light emission points of a light source with respect to a single mask pattern generated in a spatial modulation element, a pixel shift amount of the mask pattern determined by a position of the light emission point to be turned on of the light source is known, the target object is irradiated with mask images according to a plurality of mask patterns depending on the positions of the light emission point of the light source and the spatial modulation element, and a computer calculates a correlation between a light intensity detected by a detector and the mask image with which the target object is irradiated, to construct an image of the target object. With this, an imaging device and an imaging method capable of achieving an increase in speed of mask pattern irradiation in single-pixel imaging and significantly increasing an input speed of single-pixel imaging are provided.

Imaging method and imaging device calculating the correlation between light intensity and a spatially modulated mask image to construct an image of a target object

A determination method of non-destructively and easily determining a state of an aggregate of a plurality of cells formed by three-dimensional culture is provided. A determination method according to the disclosed technology includes generating a phase difference image of an aggregate of a plurality of cells from a hologram obtained by imaging the aggregate, deriving a phase difference amount density by dividing a total phase difference amount that is a value obtained by integrating a phase difference amount of each of a plurality of pixels constituting the phase difference image by a volume of the aggregate, and determining a state of the aggregate on the basis of a time transition of the phase difference amount density.

Determination method

Provided is a determination method capable of non-destructively and simply determining a state of a sphere that is an aggregate of a plurality of cells. A phase difference image of a sphere that is an aggregate of a plurality of cells is generated from a hologram obtained by imaging the sphere, and a state of the sphere is determined on the basis of the phase difference image and a shape index value corresponding to a shape of the sphere.

Method for determining a state of a sphere

A determination method of non-destructively and easily determining a state of an aggregate of a plurality of cells formed by three-dimensional culture is provided. A determination method according to the disclosed technology includes generating a phase difference image of an aggregate of a plurality of cells from a hologram obtained by imaging the aggregate, deriving a first index value that indicates a randomness of an array of a phase difference amount in a plurality of pixels constituting the phase difference image, and determining a state of the cells constituting the aggregate on the basis of the first index value.

An image processing apparatus includes an acquisition unit that acquires a hologram obtained by imaging a plurality of granules contained within an imaging visual field, a generation unit that generates, from the hologram, phase difference images at positions different from each other in an optical axis direction in a case in which the hologram is captured, a specifying unit that specifies a plurality of image ranges in a direction of a plane intersecting the optical axis direction, which correspond to the plurality of granules, in an averaged image obtained by averaging at least some of the phase difference images, and an extraction unit that extracts the phase difference image at a center position of a corresponding granule in the optical axis direction for each of the plurality of image ranges.

Image processing apparatus, evaluation system, image processing program, and image processing method

In an optical coherence tomography apparatus that generates a full-color optical coherence tomographic image, an image generation unit includes a correction processing unit that calculates an attenuation related value related to attenuation of signal intensity of the interference light of three R, G, and B colors in a first depth region and corrects the signal intensity of a second depth region deeper than the first depth region according to the attenuation related value to calculate a correction signal for the interference light and generates a full-color optical coherence tomographic image using the correction signals calculated for each of R, G, and B.

Optical coherence tomography apparatus and measurement method

Using an optical tomography method of splitting low coherent light into sample light and reference-light, emitting the sample light to a measurement-target in a line shape, generating interference light by superimposing reflected light from the measurement-target due to emission of the sample light and the reference-light on each other, and acquiring a two-dimensional spectroscopic tomographic-image of the measurement-target by spectroscopically detecting the interference light and performing frequency analysis, an arbitrary wavelength region in an ultraviolet region is cut out from low coherent light including a wavelength region from an ultraviolet region to a visible region and the arbitrary wavelength region is shaped into a spectrum having an arbitrary wavelength width, the two-dimensional spectroscopic tomographic-image is acquired as using the low coherent light, and the penetration depth of the sample light for the measurement-target is evaluated based on the two-dimensional spectroscopic tomographic-image.

Light penetration depth evaluation method, performance test method using evaluation method, and optical tomography apparatus

There is provided a dynamic light-scattering measuring apparatus including: a Mach-Zehnder interferometer; and a low-coherence light source. Further, there is provided a method for measuring light-scattering intensity of particles in a medium, including the steps of: providing a Mach-Zehnder interferometer; and measuring light-scattering intensity from light emitted from a low-coherence light source, in accordance with a dynamic light-scattering intensity measuring process.

Growing community of inventors

Ashigarakami-gun, Japan

Sohichiro Nakamura