Kimberly-clark Worldwide, Inc.

Sohail Malik

Stephen Quirk

Dave Allen Soerens

Sharon Linda Greene

Julie M Villanueva

Archel A Ambrosio

Lei Huang

Yanbin Huang

Shu-Ping Yang

Rameshbabu Boga

Ilona F Weart

Jason Patrick McDevitt

Cameron G Rouns

Robert B Johnson

Rosann M Matthews Kaylor

Sharon L Greene

The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.

Wound and skin care compositions

The invention provides compositions and methods for increasing cell growth, stimulating cell turnover and promoting the secretion of mucus within the reproductive tract of a female mammal.

Vaginal health products

Wound and skin care products

Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly, inhibitory compounds identified by the disclosed methods may be utilized to prevent and treat damaged tissue, inflammatory conditions, cardiovascular conditions, renal conditions, periodontal conditions and obesity, among other conditions. For example, the compounds identified by the disclosed methods may be utilized to treat tissue that has suffered trauma, e.g., burns or wounds, as well as tissue that is inflamed due to any of several causes. The disclosed compounds may also be utilized to improve the accuracy of assays designed to assess CRP or Fn levels in a sample, for instance in a plasma sample, as a risk assessment tool in certain medical conditions and to discover new treatments.

Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin

The invention provides compositions and methods that employ compounds that can promote skin cell renewal, wound healing, proliferation of fibroblasts and/or keratinocytes, and production of collagen or fibronectin by fibroblasts. These compositions and methods are useful for rejuvenating the skin and for treating wounds as well as gum-related and skin-related conditions.

The invention provides compositions and methods for conditioning the skin and reversing the effects of aging on the skin.

Skin care products

The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.

Anti-microbial composition and methods of use thereof

The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.

Anti-aging and wound healing compounds

The invention provides peptides, and compositions containing those peptides, that increase the amount of fibronectin in tissue. These compositions are useful for encouraging the maintenance and development of healthy skin, for preventing and treating wrinkles, and for treating wounds. The peptides can be formulated into therapeutic compositions, lotions, creams, skin coverings and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling, and ameliorate the effects of healing.

Method to increase fibronectin

A wound dressing includes a first layer located adjacent the wound and which comprises a material that is bioabsorbable, porous and adapted for serving as a scaffold for cell attachment and proliferation; and a second layer which is in contact with the first layer and which comprises an absorbent, gel forming material adapted for serving as a barrier to cell adhesion and penetration. A method of treating a wound with the dressing is also disclosed.

Bioabsorbable wound dressing

A bandage of the type used on acute wounds, minor wounds, burn wounds and irritations, includes a first layer for covering the wound site and an area around the wound site, with the first layer including a top surface and bottom surface; a second layer over the first layer bottom surface, for absorbing exudates from the wound site; the second layer including a poly(ethyleneoxide)-based compound and a chitosan-based compound. A third layer is situated over the second layer, the third layer being of a perforated film, and wherein, at least one antimicrobial agent is associated with the bandage in a position where the antimicrobial agent will come in contact with the wound site, and which is transferable from the bandage to the wound site, upon contact with the wound site.

Growing community of inventors

Roswell, GA, United States of America

Sohail Malik