Janssen Pharmaceutica Nv

Sofie Jeanne Leopoldine Celen

José Ignacio Andrés-Gil

Guy Maurits R Bormans

Andrés Avelino Trabanco-Suárez

Jérôme Emile Georges Guillemont

Michiel Luc Maria Van Gool

Maarten Vliegen

Frederik Jan Rita Rombouts

Manuel Jesús Alcázar-Vaca

Peter Jacobus Johannes Antonius Buijnsters

Meri De Angelis

Greta Constantia Peter Vanhoof

Joost Verbeek

Manuel Jesús ALCÁZAR-Vaca

José Ignacio ANDRÉS-Gil

The present invention relates to novel, selective, radiolabelled mGluR2 ligands which are useful for imaging and quantifying the metabotropic glutamate receptor mGluR2 in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a mammal, in vitro or in vivo and to precursors of said compounds.

Radiolabelled mGluR2 PET ligands

The present invention relates to novel 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]-quinoxaline derivatives as inhibitors of phosphodiesterase 2 (PDE2) and to a lesser extent of phosphodiesterase 10 (PDE10) or as inhibitors of both, phosphodiesterases 2 and 10. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, or disorders in which both PDE2 and PDE10 are involved, such as neurological and psychiatric disorders, and endocrinological or metabolic diseases. The present invention also relates to radiolabelled compounds which may be useful for imaging and quantifying the PDE2 enzyme in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.

1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

The present invention relates to novel, selective, radiolabelled PDE10 ligands which are useful for imaging and quantifying the PDE10A enzyme in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo.

Radiolabelled PDE10 ligands

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Tessenderlo, Belgium

Sofie Jeanne Leopoldine Celen